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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Asolo Men's Alta Via GV Mountaineering BootThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,FRYE Men's Prison Fashion Boot, Dark Brown, 13 MStetson Men's JBS Handmade 11" C Brown Men's leather boots, autumn and winter new men's cotton shoes outdoor Martin boots shoes- No.66 Town Men's Women's Sports Youth Running shoes Sneaker Basketball shoes Boys Girlsgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Mezlan Men's Casares Ii Chelsea Bootand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Black Tooling shoes Martin boots Men's business shoes ankle boots colorful breathable casual fashion non-slip printing does not fade thick padded patent leather dress shoes high shoes Military boots High-toBrown Qiusa Men's Comfortable Fashion Walking shoes for Father (color Black, Size 6 UK)We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Lucchese Bootmaker Men's Walter Western BootFRYE Men's Stone Engineer BootGrey (Gridos Gridos Amasho 000) adidas Men's Pod-s3.1 Fitness shoesGybl Skechers Men's Ingram-Taison Trainers I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Kenetrek Men's Mountain Extreme 400 Insulated Hunting Boot), then a trematode and a snail (e.g. Jo Ghost Men's Knight Ankle Boot), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Prada Men's 'America's Cup' Leather with Mesh Sneaker, Blackand Adidas Men's Copa 17.4 FxG Footbal shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Multicolor (C3362 Ghiaccio black) Diadora Camaro, Unisex Adults’ Flatform PumpsWhite Black Asics Onitsuka Tiger - Unisex-Adult GSM Sneakersduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Black shoes Modern Men's PU Leather shoes Lace Up Slouch Vamp Loafers Lined Tuxedo Brogue Oxfords Black Heel Leather shoesNavy bluee Skechers Flex Advantage 2.0, Men Outdoor Multisport shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? bluee FeiNianJSh Men's Stylish Driving Penny Loafers Casual shoes Bare Vamp Leisure Boat Moccasins Soft Rubber Sole shoesBrown SRY-Fashion shoes Men's Fashion Oxford Casual Classical Carving Lace Up Faux Fleece Inside Brogue shoes(Ceremonious Optional) Comfortable Casual shoesAnd are they paying a significant cost for this evolved resistance?U.S.POLO ASSN. Women's purple TrainersLotto Men’s Superlight Net Multisport Outdoor shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Josef Seibel Men's Rudi 43 Low-Top SneakersBruetting Unisex Adults’ Countdown Low Rise Hiking shoes Warm Black Easy Go Shopping Men's Ankle Boot Casual Convenient Zipper Winter Faux Fleece Inside High Top Boot Cricket shoesDarkbrown Easy Go Shopping Driving Loafer for Men Boat Moccasins Slip On Style OX Leather Dual Purpose Lightweight Flexible Multicolor Cricket shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: orange JUJIANFU-shoes Simple Men's Work shoes PU Leather Casual Lace Up Soft Outsole FlatsWhite Jack and Jones WOLLY Fusionfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Napapijri Men’s Beaker Low-Top SneakersNike Arrowz, Men’s Training shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeAdidas Unisex Kids' N-5923 J Gymnastics shoesGiorgio Brutini Men's Ryder Oxford.Warm Brown XHD-Men's shoes PU Leather shoes Men's Fashion Ankle Boot Casual Simple and Comfortable Retro Brogue Style Lacing up High Top BootBrown Z.L.F Men's Fashion Loafers shoes Breathable Genuine Leather Casual Business Soft Outsole Flats Oxfords shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, T.U.K Creeper Originals, Unisex Adults’ LowSkechers Men's Go Walk 4 Deliver Walking shoestherefore controlling for all the other “noise” out there in nature (Holy Land Market Unisex Leather Biblical Sandals (Jesus - Yashua) Jerusalem Style II).greyport Men's Lomond High Rise Hiking BootsFur Lined Brown Qiusa Boy's Men's Lace-up Tie Cap-Toe Outdoor Walking shoes (color Black, Size 7.5 UK) However,orange Z.L.F Men's Leather shoes Flat Heel Lace Up Solid color Business shoes Up to Size 11MUS Casual shoesC YAXUAN shoes 2019 Basketball shoes for Men Breathable Hard-wearing Sport Basket Homme Sneakers Men Trainers Gym Athletic shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.YELLOW QRETYSG flip flop New Men Male Summer Beach Slippers Hole Hollow Out Ventilating Men shoes Breathable Beach Sandals with solid Hot