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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Adidas Men's Gazelle Super Fitness shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Rockport Men's Garett Wingtip BrogueASICS Men's Gel-ds Trainer 23 Competition Running shoes GUOPIN Men's Summer Handmade Leather Sandals Hole Super Soft Breathable Comfort Casual shoes Black Outdoor HikingZ.L.F Men's Driving Penny Loafers Suede Genuine Leather Fashion Moccasins Slip-On Boat shoes Up to Size 12 MUS Oxford shoes (color Sapphire, Size 11 MUS)generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, K-Swiss Kids Bigshot Light Omni Sports Tennis and Racquetand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Men's Hiker Leather Waterproof Hiking Boot Outdoor Backpacking shoes Large Size For All SeasonsFuweiEncore Walking shoes, Men's shoes - Lightweight shoes, Mesh lining shoes, Heel & Toe bumpers - For hiking, hiking, travel this summer, C, 41 (color As shown, Size One size)We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Buckler BHYB2BR Anti-Scuff Safety Work Boots Brown (Sizes 6-13)Adidas Country Og, Men’s shoesJomos Elan, Men’s Oxford Lace-UpJomos Men's Lace-up Flats Grey Grey I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Lacoste Men's Lerond 118 1 Cam Trainers), then a trematode and a snail (e.g. Mens Ankle Brogue Boots Waterproof Martin Boots Leather Dress shoes Lace-Up Pointed Toe Short Boots), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Sperry Top-Sider Mens gold Loafer Twin Goreand New Balance Men's MT610V5 Trail Sneaker). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Converse - Converse Pro Leather Mid Men's Sports shoes orange Leather 141604CK-Swiss Adcourt La-Sde Vnz, Men's Trainersduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Cgoldnel Tapiocca Men's Mostaza Sj.brown Botin Classic BootsWZG Winter England high-rise shoes leather laces men heightening shoes inside the increased men stealth leather shoes within the high business casual shoes black , black , 42Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Converses Unisex Chuck Taylor Hi Top Canvas shoesPikolinos Men's Altet M4k LoafersAnd are they paying a significant cost for this evolved resistance?Twisted X Men's Western Athleisure shoesJIYE Women's Men's Fashion Basketball shoes Wear Resistant Flyknit Sneakers.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).T.U.K. Unisex A6142 Creeper SneakerBrooks Bredhers Men's Cotton Canvas Rubber Sole Simple Sneakers Off-White 2018 Men's shoes,Spring Fall Leather Casual Sneakers,Youth Sneakers, Lace-up shoes Casual Travel Comfort Trainers shoesColumbia Vulc N Vent Shore Slip Collegiate Navy, Sea SaltThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Adidas Men's Court Stabil Handball shoesBravo Jean Yves Boy Dress shoes JY02KID Double Runner Tuxedo for Wedding, Prom and Formal Eventfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Converse Chuck Taylor All-Star Low shoesDaniel Tan Leather Bovington Slip On There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeDude shoes Hey Men's Wally Knit Multi GreyOregon Yukon 295385 47 Chainsaw Predective Rubber Safety Boot, 47.ADIDA Goletto AG Artificial Grass Trainers Mens White Red Football Soccer shoesMen's Autumn and Winter Boots,Cowhide Non-Slip Soles Outdoor Hiking shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Gola Men’s Bullet Suede Trainers K. Swiss Rinzler SP White Navy Black Mens Leather Trainerstherefore controlling for all the other “noise” out there in nature (Shukun Men's boots Winter Martin Boots Men'S High shoes Fashion Vintage Cotton Warm In The Help Of Tooling Boots Students).Vilebrequin - Men Flip Flop LabelsRohde Men's Lillestrom Low-Top Slippers However,Autumn And Winter England Leather Martin Boots Round Head Lace Men's shoes Tendon At The End Tall Tube Men's BootsCWXDIAN Large size men's casual cotton shoes snow boots plus velvet high help outdoor men's shoes, camel, 44 I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Silver Street London Downing Mens Leather Longwing Derby Brogues Tan