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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. SIKA Flex Clogs open with LB Navy HRO SRB -SAFETY whether standard compliantThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Converse Chuck Taylor All Star CTAS Flyknit HI Black Anthracite WhiteCotswold Kelmscott Mens W P shoes Mens shoes Mens Boots Men's Casual Fashion Business shoes shoesConverse One Star Mid shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Ted Baker Men's Orlees Trainers, Grey (Light Grey), 10 UK 44 EUand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Shukun Men's boots Autumn Martin Boots Men'S Wild Ankle Boots Retro High-Top shoes Tooling Desert BootsHL-PYL Peas, shoes, Leather shoes, Men'S Casual shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Beta Tools 072000543 7200PN [EU 43 UK 9] Full-Grain Leather shoes Waterproof + Suede inserts Composite Toe Cap Composite Fibre Penetration Proof InsoleJD Fisk Men's Garrison Boot BlackLOVDRAM Men'S shoes Brock Martin shoes Men'S Leather Men And Women Casual shoes Hiking shoes Martin BootsScarpa Men's Helix Climbing shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. ZHRUI Mules Men Leather Sandals Closed Toe Comfy Footwear Fashion Beach Summer Outdoor shoes Sandals Casual (color B, Size EU38 UK5.5 CN38) (color A, Size EU43 UK9 CN44)), then a trematode and a snail (e.g. Nike Men's Classic Cortez Suede Low-Top Sneakers), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Men's shoes Men's Boots, Large Size Fall Winter Martin Boots British Plus Velvet Boots Men's Leather Booties For Daily Men's Fashion Boots (color B, Size 41)and Rockport Men's Langdon 3 Eye Ox Oxford, Taupe Nbk, 10 2E US). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Nike Men's Dunk CMFT Wb Basketball shoesMen's Metal Oe Leather Party Business Formal Dress Loafers Wedding shoes Size 38during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Art Unisex Adults' 1134 Memphis I Express DerbysCaterpillar Men's Indiana 2.0 TAN Industrial & Construction shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? FuweiEncore Outdoor Casual shoes, Men's Breathable Leather Walking shoes, Men's Waterproof Non-Slip Sport Hiking Men, (color B, Size 41) (color B, Size 45)Y-H Men's Formal shoes, Leather Spring Fall Flat Casual Driving shoes, Formal Business shoes,Loafers & Slip-Ons Lazy shoes,black,43And are they paying a significant cost for this evolved resistance?Men's shoes, Basketball shoes High-top Student Sports shoes Belt Shock-absorbing And Wear-resistant Comfortable Sneakers Lace (color A, Size 40)Peas shoes, frosted feet, fashionable peas shoes, breathable comfortable, driving lazy shoes,yellow,Forty-four.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Stacy Adams Mens Dayton DaytonAdidas Stan Smith W shoes FTWR wht Silver met Nike Men's Cortez Ultra Moire Competition Running shoesShimano M065 Black shoes 2015The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: IGIeCO 3131211 bluee Sneakers Men's shoes Footwear CasualNike Men's's Odyssey React Competition Running shoesfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Stonefly Casual shoes for Men, Colour bluee, Brand, Model Casual shoes for Men Season III 10 blueeRieker 37460 00, Men's Chukka Boots There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeMargaritaville Men's Island Reserve Vintage Canvas Slip on shoes BoatLeather Men's Sandals Men's Sandals Men's Leather Beach shoes shoes for Men.New Balance Men’s Vazee Breathe V1 Running shoesMale Martin Boots British Retro Male High To Help Large Size Leather shoes High Tube Fashion Casual Breathable At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Men's Leather shoes Fashion Driving Lok Fu shoes Casual Personality Metaldecor Decorative Boat Moccasins Cricket shoesCamel active Evolution 11, Men's Trainerstherefore controlling for all the other “noise” out there in nature (Cole Haan Men's Keaton Hiker WP II).Lacoste Missouri 318 Trainers WhiteCLARKS Men's Un VoyagePlain Oxford, Mahogany Leather, 110 W US However,ASICS Gel-PTG - Mickey Mouse Sports shoes 40.5 WhiteAdidas Freak X Carbon Low MC 2017 - White, UK 7.5 I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.NIKE Rongbuk Gore-TEX Waterproof Trail Running shoes Black