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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. JUJIANFU-shoes Classic Men's Genuine Leather shoes Slip-on Breathable Perforation Soft Flat Sole Loafer Comfort shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,QRETYSG flip flop Men Slippers Summer shoes For Man Beach Slippers Outside slippers Men Casual shoes Microfiber Printing 4 colorsFila Skele-Toes Emergence Black Castlerock Mens Hiking Size 13M Josef Seibel Men's Carlo 03 Sling Back SandalsMens BLACK Amblers Aldershot Leather Gibson shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, ZHRUI Men Sandals Air Mesh Genuine Leather Outdoor shoes Breathable Loafers Slippers (color Yellow, Size 5.5=39 EU)and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. English Laundry Men's Envy Chukka BootSALOMON Unisex Kids’ Speedcross CSWP J Trail Running shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Onitsuka Tiger Mexico Delegation Trainers Green 12 UKMzq-yq Men's Canvas shoes Spring And Autumn High To Help Korean Version Of Cloth shoes Men's shoes England Casual shoes Pu Leather Casual Men's shoesFrank Wright Truro Ankle Boots Mens shoes FootwearLoafers Men'S Hair Stylist Rivets Foot shoes Pointy shoes Comfortable Casual shoes Trend Party shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Puma Serve Pro Rl Bk Red Wh, Men’s Hi-Top), then a trematode and a snail (e.g. KEFAS - Suede Italian shoes, Vibram Sole + EVA, Globelite purple Crocus 41), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, POLO RALPH LAUREN Men's Thompson Sneakerand Josef Seibel Men's Thaddeus 01 Sneaker). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, LIJUN Snow Boots Men Winter Non-slip Warmest Snow Boots Genuine Leather Handmade Winter shoes Size：38-43,Black-EU41 UK7.5-8 US8.5-9Shiney 2018 New Men's Business Dress shoes Patent Leather shoes Lace Up Wedding Casual shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). LEDLFIE Sandals Men's Beach shoes Outdoor SandalsAutumn And Winter, New, Men, shoes, Leather, Lace, Leisure, Single shoes, Driving shoes, Work shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? DIESEL Men's Sneaker Lace-Ups VOLCKRAN S-KWAARTZZBase London Hike Boots TanAnd are they paying a significant cost for this evolved resistance?Adidas Unisex Adults' Haven TrainersWilson KAOS 2.0 Safety Yellow WRS324410, Tennis.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Cofra COF906-45 Typhoon Safety Wellingtons, Size 45, bluee Red (Pack of 2)Puma Faas 600 V2 Mens Running shoes, Red Silver Black ZJ Men's Boots, Fall Winter, Casual Low-Top Boots, Loafers & Slip-Ons Driving shoes, Personality Martins Style, Outdoor Walking shoes, Ankle BootsINMONARCH Mens bluee Traditional Wedding shoes MJ0010The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Reebok Men’s R Crossfit Speed Tr Fitness shoesSHOESDQ Adult Male Summer Outdoor Leisure Wading Beach Slippersfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Jiang-ZX Men's shoes，New Men's Leather shoes British Retro Pointed Male Trend color Bright Leather Business Wedding shoesLotto Record VII, Men’s Low-Top Sneakers There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeMen's Sneaker Spring and Summer Breathable Casual shoes White Running shoes LeisureWork shoes Men's and women's safety shoes puncture predective shoes steel toe caps safe work boots, rubber outsole non-slip, wear-resistant fashion work boots flying woven mesh breathable deodor.SRY-Fashion shoes Men's Fashion Oxford shoes Casual Comfortable Low-top Lace Up Round Toe Formal Big Size Work shoesLOVDRAM Boots Men's Winter Snow Boots Men'S Cotton Padded Warm Martin Boots Waterproof Non-Slip Warm Cotton shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, LOVDRAM Men'S Leather shoes Autumn Men'S shoes Fashion Men'S Casual shoes Retro Men'S Leather shoes Matte Leather Men'S shoesNike Legend VII Academy FG Fast AF Packtherefore controlling for all the other “noise” out there in nature (Adidas Nitrocharge 1.0 Fg, Men’s Football Boots).SG Footprints SGF2-B-41 Unisex High Top Printable Canvas shoes, Size 41, BlackLiberty Men's Handmade Leather Dress Cap-Toe Oxford shoes However,Florsheim Men's Hamilton Chukka Boot, Cognac, 13 D USDr. Martens 21156067 Sneakers Man I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Aro Unisex Adults' Ido Low-Top Sneakers