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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. SHANGWU Men's Leather Boots Plus Velvet Leather Men's Cotton Boots Stylish Boots For Work Or Casual WearThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Lumberjack Men's's Leman LoafersYVWTUC Male Winter Sports shoes Large Size Air Cushion Cotton Basketball shoes Mark Nason Men's Monza Slip-On LoaferGUOPIN Summer Leather Sandals Men's Fashion Beach shoes Matte Comfortable Baotou Handmade shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, DANDANJIE Leather shoes Men Outdoor Sports shoes Winter Warm Lace Up Low Top Driving shoes Black Brownand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Bloch 301M Mens Jazz Tap shoesXxoshoe Men's Lightweight Slip On Mesh Sneakers Outdoor Athletic Running shoes Casual Sport shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Men's shoes Feifei Non-Slip Fashion Keep Warm Cotton shoes 2 colors (color 02, Size EU 41 UK7.5-8 CN42)ASICS GEL-LYTE V 30 Years Of Gel Adult's Sneakers (DN6K4)Kenneth Cole Mens C-Roam Closed Toe Ankle Fashion BootsQIKAI Hiking shoes Outdoor sports hiking shoes non-slip thick-soled casual shoes Green-EU44 270mm UK9.5 I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Adidas Men's's Cloudfoam Advantage Clean Sneakers), then a trematode and a snail (e.g. QRETYSG flip flop Men Home Bathroom Slippers Couple Summer), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, ZHRUI Men Sandals Retro Summer shoes Genuine Leather Slippers Men Beach shoes Cow Leather Outdoor Casual Sandals (color Brown, Size 9.5=44 EU)and Fila Men's Skele-Toes Emergence shoes Black, Black Castlerock, 11). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Mens Leather Walking Sandals Sport Hiking Summer shoes Sports leisure beach shoes outdoor lightweight breathable large size sandalsSnfgoij Work shoes Men Trainers Waterproof Anti-Slip Casual Autumn Winter Martin Boots Plus Velvet Snow Boots Military Boots to Keep Warmduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Silver Street Milton shoes TanZLLNSPX Mens Casual Leather shoes Slip-on Everyday ComfortableLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Men's Leather shoes Genuine Leather Carved Block Men's shoes Casual shoes England Trend shoes shoes,Yellow-brown-38CLARKS Bushacre Ca Mens Green Canvas Casual Dress Lace Up Chukkas shoesAnd are they paying a significant cost for this evolved resistance?Converse Alll Star Sneakers black shoes Unisex impermeabili Water ResistentKEFAS - Suede Italian shoes, Vibram Sole + EVA, Globelite Yellow Moutarde 38.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Cole Haan Men's Boothbay Slip-on LoaferReebok Classic Leather Ripple SN Men JIALUN-shoes Fashion Men's Brogue shoes Lace Up Breathable Oxfords High Top Ankle Boots for GentlemenRENMEN Spring Summer Men's Business Casual shoes Formal Wear Leather shoes Lace-up Low-cut shoes 38-43The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Zerimar Men's Sandals Men's Trekking Sandals Sandals Man Hiking Men's Leather Sandals Men Summer Sandals color Navy bluee Size UK 7.5 EU 41Leisure shoes retro running shoes men's wear sports shoes Low top sneakersfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Adidas Superstar Foundation, Unisex TrainersPerry Ellis Men's Christian Loafer There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeSandals Men's Flip Flops Non-Slip Beach SummerPITILLOS Heeled shoes, Colour bluee, Brand, Model Heeled shoes 5281P bluee.Men's Classic Genuine Leather With Leather Soles. Black Leather Mens Classic Style Formal shoes Lace UpUnlisted by Kenneth Cole Men's Design 30414 Loafer At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Nike Men's Arrowz Fitness shoesYVWTUC Men's Flat Basketball shoes Training Durable Sneakers Male shoestherefore controlling for all the other “noise” out there in nature (Gym wear for men Men's suede leather hiking shoes waterproof non-slip low waist thin section non-slip casual shoes outdoor path walking shoes on cloud running shoes (color Yellow, Size 44)).Dr. Martens Jorge II Black SandalMen's Handmade Moccasin-Gommino Leather Low Cut shoes Comfort Flats Business shoes Boat shoes Driving shoes Loafer Flats However,LOVDRAM Boots Men's Men'S Chelsea Short Boots Winter Cotton Casual High-Top Martin Boots Vintage Snow Boots Cotton WildSkechers Mens Navy 'Equalizer Timepiece' Trainers I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Men's shoes Leather Spring Summer Comfort Loafers & Slip-Ons For Casual Office & Career Outdoor shoes Black Brown,Brown,38