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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Converse Chuck Taylor All Star Ox, Unisex Adults’ TrainersThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,VALLEgreen Sandal Man Brown Leather 20830 Model Comfort with Insole Comfort. Leather shoes Spring Summer 2019Dude shoes Hey Men's Farty Print Red Slip On Mule MTNG Men Sports shoes 84138 C42646 MarinoDeltaplus Delta Plus Capps LH832SM S3 Black Leather Mens Safety Boots Steel Toe Cap Work Bootgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Mens Dude Wally Perforated Tan shoes - 46 EU, Brownand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. QRETYSG flip flop Spring Summer Beach Sandalias shoes Men Sandals for Male Casual New Classic Walking Sandals Green blueeMen's Fashion Driving Loafer Casual Solid color Comfortable Convenient Carving Brogue Big Size Boat Moccasins Cricket shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,XTI Men’s 046459 Oxfords, blueePerf PB17C DDR S3 SRC Safety Chukka Boot C W Cap, Black, 7 UK (41 EU)XTIANUK Mens Casual Trainers Canvas shoes, Coarse Fabric Comfort Low Top Flat shoes Cotton Lining Walking Sneakers Size 2-10LOVDRAM Boots Men's Winter Thick Warm High shoes Men'S Cotton shoes Leather Casual shoes Fashion Martin Boots In The shoes Men I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Nike Men's Md Runner 2 Se Gymnastics shoes), then a trematode and a snail (e.g. Adidas Men’s RIVALRY LO Sneakers multicolord Size 7 UK), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Shukun Men's flip flops Flip-Flops Men'S Summer Non-Slip Sandals And Slippers Personality Pinch Outdoor Beach shoes Men'S Sandalsand Ben Sherman Men's Adair Derbys). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Motorcycle shoes, Motorbike Accessories, Motorbike Boots, Soft Motorbike Boots, Waterproof Motorcycle Boots Speed Motocross Boots Non-Slip Motorcycle shoes 8 BlackNunn Bush Men's Sherman Slip-Resistant Work shoes Oxfordduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Vw165 thames pu coated nylon body chest waders with pvc wellington boots steel toe cap and midsole predectionMens Martin Boots Winter Snow Ankle Boots Leather Round Toe Warm shoes Comfortable Non-Slip Work Safety shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Snfgoij Tactical boots men black hiking breathable lightweight Military boots fashion comfortable wear-resistant shock absorption hiking bootsFoxter - Safety shoes for Men High Comfort Work Trainers Breathable Waterproof Composite Toe Cap Leather Black S3 SRC HROAnd are they paying a significant cost for this evolved resistance?GLSHI Men Outdoor Martin Boots Men's Autumn England Short Boots Retro Leather Boots High to Help Desert Tooling shoesMen's Fashionable Ankle Boots, Casual OX Leather Lace Up Round Toe Work shoes (color Brown, Size 35 EU) (color Brown, Size 39 EU).
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Dexter Womens Katie bluee FloralSHOESDQ Men's Running shoes Fashion Sneakers Four Seasons Leisure (color White1, Size 38EU 5US) ASJUNQ Cross-Country Running shoes Sports Non-Slip Hiking shoes,Armygreen-43Snfgoij Tactical Boots Men Sand Combat Breathable Lightweight Outdoor Desert Army Boots High Help Assault BootsThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: LINYI Men'S Genuine Leather Casual Martin Boots First Floor Cowhide Pure Wool Tooling shoesMark Nason Los Angeles Men's Bayshore Dress Knit Slip-On Loaferfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Puma Tsugi Jun shoes purple Quiet Shade WhiteGeox Men's U Leitan B Mocassins There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeshoes Men's PU Leather shoes Square Texture Upper Lace Up Breathable Business Modern Block Heel Lined Oxfords Leather shoesMen's shoes Feifei Non-Slip Fashion Keep Warm Cotton shoes 2 colors (color 01, Size EU42 UK8.5 CN43).WDDGPZYDX sneakers Fashion Red non-slip Comfortable casual shoes adult Sapato masculinos Light and breathable Black Men shoesDC shoes Trase TX - shoes for Men - shoes - Men - EU 36.5 - Red At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Men's Leather Hiking shoes Outdoor Mesh Sports shoesFila Crescendo Slip ON Mens shoestherefore controlling for all the other “noise” out there in nature (Onitsuka Tiger Mexico Delegation Trainers Green 12 UK).Bugatti Men's 323396313000 Chelsea BootsSHANGWU Men's Leather Lined Oxfords Dress Ankle BootsMartin Boots Men's Leather Chelsea Bullock Carved England Men's Boots However,INMONARCH Mens orange Designer Wedding shoes MJ0126LHLWDGG.K Men'S shoes Leather Men'S Dress shoes Men'S Business Casual Classic Men'S Official shoes Men'S Oxford shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Aigle Unisex Adults’ Benyl M Wellington Boots