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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. CAFèblack Cafè black CAF black QH930 Sand Beige Mid Fabric Men's shoes SneakersThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,HAOYUXIANG Men's sandals leather summer tide British wild casual shoes youth clip toe men's slippers beach shoes (color Yellow, Size 39)Exton 695 Ankle Boots Man Brown 44 Trussardi Jeans Men’s Running Gymnastics shoesAldo Men's ALUER Trainers, blue (Navy Miscellaneous 4), 9.5 UK 9generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Kelme Adults' Trueno Sala Low-Top Sneakersand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. New Balance Men's 608v1 Casual Comfort Cross TrainerFRETZ men Men’s Meran Trainers, Black, 8.5 UKWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,LOVDRAM Men's shoes Fashion shoes Spring White Fashion Men'S shoes Students Winter New shoes Youth White shoesAdidas Tubular Viral W - S75907 -Easy Go Shopping Driving Loafer for Men Boat Moccasins Slip On Style Cowhide Leather Simple Pure color Low Top(Hollow optional) Cricket shoes (color Black, Size 9.5 UK)SHANGWU Joker Side Zipper Leather Boots High To Help Plus Velvet Warm Men's Boots Stylish Boots For Work Or Casual Wear I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Adidas Busenitz Vulc crystal white black white shoes size US 13,5), then a trematode and a snail (e.g. Van Heusen Men's Sandro Black 11 D US), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Deer Stags Men's Animal, Black, 8.5 W (3E) USand Y-H Men's Casual shoes, Spring Fall Outdoor sports shoes Flat Deck shoe Comfort Driving shoes Cycling shoes,Black,42). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, YAXUAN shoes Men's shoes, Spring Autumn Trainers Lace-up Running shoes, Outdoor Lightweight Shock Absorption Breathable Casual Walking Sport shoesMen's Flat Heel Driving Loafer Leisure Style Slip on Wave Sole Moccasins shoes Cricket shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Camouflage shoes Winter Plus Velvet Cotton shoes Rubber shoes Men's Autumn and Winter Canvas shoesDANDANJIE Men's Athletic shoes 2018 Fall Winter Comfort Hiking shoes For OlderLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Men's shoes Feifei Winter Retro Leisure Wear-Resistant Non-Slip Leather shoes 4 colors (color 04, Size EU39 UK6.5 CN40)GLSHI Men British Casual shoes Breathable Flat shoes Fashion Leather Driving shoes Hand-woven SolesAnd are they paying a significant cost for this evolved resistance?Geox Men's Damian 5 Fashion SneakerLianaiec Men's boots In The Desert High Top Martin Boots Couple Tooling shoes Big Heads Increase Men And Women Autumn And Winter 34 Khaki Single.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).XIANGBAO-Personality Men's Classico Business Oxford Casual Fashion New Solid color Vintage Outsole Increased Waterproof Brogue shoesDjinns Men's Running shoes Beige Sand David Spencer Men's Montgomery BootMens Pointed Toe Chelsea Boots Autumn Winter Short Ankle Boots Zipper Business Dress shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Flat shoes Men'S Casual Leather shoes With Martin Boots Wear Peas shoes Outdoor Desert BootsSpring Men'S Casual shoes Round Head Peas shoes Solid color Flat shoes Work shoes Outdoor Travel shoesfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Vans Comfycush Classic Slip-On Black Checkerboard TrainersDude shoes Hey Men's Mikka Sox Sage There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeDiadora M. Winner RB LT TFNike Mens Air Fantaposite Max.Outdoor Mountaineering shoes Mens Combat Tactics Assault Martin Army Boots Special Forces Military Police Armed shoes Trained BootGTYMFH Autumn and Winter Men's Leather Casual shoes Breathable Men's shoes Fashion Driving shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Nike Men's Md Runner 2 Se Gymnastics shoesFuweiEncore 2018 Mens Business shoes Smooth PU Leather Splice Zipper Decoration Slip-on Breathable Mesh Oxfords (color Brown, Size 42 EU) (color Brown, Size 44 EU)therefore controlling for all the other “noise” out there in nature (greyport 10242D26G Trekking shoes Man).Serafini Camp.68 High Sneakers ManFuxitoggo Men's Ankle Boots, Casual Fashion Avant-garde Crocodile Tattoo Trend Formal shoes (color Brown, Size 43 EU) (color Wine, Size 39 EU) However,Pointed Casual Men's shoes New Products Leather shoes Fashion Tide shoesClarks Men's Cotrell Step Loafers I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Yxwxz Gym wear for men Men's outdoor hiking shoes waterproof leather walking shoes low waist comfortable lightweight non-slip lace casual shoes on cloud running shoes (Size 44)