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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Mens Black Casual Safety shoes S55The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Easy Go Shopping Men's Ankle Boots Casual Personality Pig Skin Leather Large Size Suede High Top Leisure shoes Cricket shoesEasy Go Shopping Men's Fashion Boots Casual PU Leather High-top Outdoor Outsole Leisure Boots Cricket shoes Men's Casual shoes Handmade shoes Moccasins Flats Driving shoesMuck Boot Men's Muckster II Low shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Men's Fashion Ankle Boots Casual Classic Comfort High Top Martin Boots Cricket shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Flamingos' Life Kailash All Black - Trainers, UnisexCamouflage Mesh Casual shoes Men's shoes Student Running Sneakers Women's shoes Cricket shoes (color bluee, Size 38)We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Avia Men's Avi-Volante Country Walking shoesBoras Men's 3418-1187 Trainers Multicolour Grey Black WhiteXxoshoe Sports shoes Men's shoes Autumn Men And Women Breathable Flying Woven Running shoes Couple Marathon Running shoesColumbia Men's SANTIAM 2 Strap Sport Sandal I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. RUGAI-UE Ladies' heels, high heels, gauze sandals, summer thick and large code lady's sandals.), then a trematode and a snail (e.g. European And American Style Casual Socks shoes Men's Low To Help Sports Single shoes Fly Woven Breathable Men's shoes,Black,43Uk), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, SIPENGFEI Mens Martin Boots 2018 Autumn Winter Round Toe Lace Up Outdoor Tooling Bootsand Easy Go Shopping Driving Loafer For Men Boat Moccasins Slip On OX Leather British Style Metaldecor Cricket shoes (color White, Size 9.5 UK)). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Joseph Allen Men's Anthony Loafer, Black, 11 M USA-PIE Women's Lightweight Athletic Quick Drying Mesh Aqua Slip-on Water shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Flip Flops Men's Leather Summer Breathable Casual shoes Anti-Skid BreathableConverse Chuck Taylor All Star Ox Unisex shoes Menta Black White 155398FLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? XTIANUK Mens Running shoes, Lightweight Mesh Upper Low Top Sneakers Cool Anti-Shock Lace-up Casual Trainers Size 2-10 UKLOVDRAM Boots Men's Winter Thick Warm High shoes Men'S Cotton shoes Leather Casual shoes Fashion Martin Boots In The shoes MenAnd are they paying a significant cost for this evolved resistance?LOVDRAM Men'S Leather shoes Pu Sports Cotton Running Plus Cotton Padded Cotton shoes Winter Men'S shoes Leather shoes Pu Wear-Resistant Anti-Skid SnowSurvêtement baby adidas Zebra SST.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Reebok Men's Royal Smash Fitness shoesReebok Men's Club C 85 Wp Gymnastics shoes Ed Hardy Men's Fierce Tiger Print Hi Top Trainers, WhiteP.W. Minor Mens Performance Walker Low Top Velcro Walking shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Saucony Women's Triumph Iso 4 Gymnastics shoesHNGLXQ Combat Boots G-82 Leather Side Zip Army Tactical Boots Delta Military Work Army shoes Safety Ankle Boots Breathable Commando Outdoor Desert Tactical Military Patrol Boots,Beige-EU43factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.XUE 2018 New Men's shoes Microfiber Spring Fall Comfort Athletic shoes Loafers & Slip-ONS Driving shoes Walking shoes for Outdoor Formal Business WorkRENMEN Sneakers Men's Spring Summer Fall Camouflage Casual shoes Large Size Running shoes Breathable Low shoes 39-47, Dark grey There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeWZG Men 's military boots winter men' s Mianxue snow shoes warmer special forces combat boots high - fiber high - help shoes Martin boots , black , 42Tlgf Walking Boots Winter Snow Boots Warm Mens Waterproof shoes Fully Fur Lined Anti Slip Rubber Sole.Mens Trainers Slip on Lightweight Running shoes Outdoor Breathable Sneakers fashion Casual Walking SneakersSnfgoij Snow Boots Mens Waterproof Winter Boots Work shoes Leisure Lace Up Non-Slip High shoes Leather Plus Velvet Warm Martin Boots At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Nike Men's Short-Sleeved Shirt Training T-Shirt Just Do ItPuma Ignite Flash DAUNT 02therefore controlling for all the other “noise” out there in nature (Adidas Kids Zx 700 Cf I shoes).Vans Unisex Adults' Era 59 Low-Top SneakersAilj Canvas shoes, Male Summer Single shoes Canvas Upper High-top Men's shoes Casual shoes Couple shoes (White) However,ZLLNSPX Mens Driving shoes Comfortable British Style Breathable Bean shoesCotton shoes Autumn And Winter Cotton shoes Men Non-slip High Help Korean Version Leisure Plus Cashmere Warm shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Babolat - Propulse Team Clay men's tennis shoes (red bluee) - EU 41 - UK 7,5