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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Stonefly Men's shoes, Colour Grey, Brand, Model Men's shoes Season III GreyThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,ZHRUI Mens Loafers Casual Fashion shoes Flats Breathable Slip On Swims Loafers Driving shoes (color Navy White, Size 7 UK)Casual Men's shoes Leather Size 24.0cm to 27.0cm White All Seasons Wear Board shoes Leisure DANDANJIE Men Women Running shoes Couple Basketball shoes Breathable Casual shoes SneakersMen's shoes Feifei Winter Leisure Wear-Resistant High Help Tide shoes 2 Colours (color White, Size EU42 UK8.5 CN43)generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Men's shoes Leather Lazy shoes Spring Fall Comfort Loafers & Slip-Ons Mens Walking shoes Driving shoes Casual Outdoor (color Brass, Size 38)and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Y-H Men's High-top Basketball shoes Pu Spring Fall New Breathable Sneakers Student Jogging Fitness Wearable Soccer shoes Training shoes (color E, Size 41)ZHRUI Large Size Buckle Boots for Men Soft Sole Durable Non Slip Breathable Boots (color Brown, Size UK 7)We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Zxcvb Mens Trail Running shoes Breathable Athletic Casual Sport shoes Fashion Gym Sneakers PU outsoleCamel active Men's Outback 51 BootsVans SK8-Mid Reissue - US 11DorisAA-MS Men Leather Loafer shoes Driving Loafer Slip On Style OX Leather Texture Metaldecor Low Top Boat Moccasins Loafer shoes (color Black, Size 9.5 UK) I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Men's Fashion Ankle Work Boot Casual Classic All-Purpose Round Toe Winter Faux Fleece Inside High Top Boot Cricket shoes), then a trematode and a snail (e.g. Columbia Mens 1781221 Men's Tango Fisherman Sandal), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Grunland LINO CE0329 Head of Removable Plantar Man's Slippersand Men Casual Drive Loafers New Legume shoes Soft Genuine Leather Breathable Low Top Large Size Boat Moccasins For Party, Casual Or Even Formal Events (color gold Yellow, Size 8 UK)). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Super lightweight and composite safety hiker style S1P (10)Fila Mens Hometown Sneaker,White Navy Red,9.5during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Nike Men's Air Max Guile Premium TrainersHYLFF Men Running shoes,Basketball shoes Outdoor Waterproof Sneakers Lightweight Casual shoes High Rise TrainersLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Fuxitoggo 2018 Men's Genuine Cowhide Beach Slippers Casual Non-Slip Sandals shoes Adjustable Backless (color Brown, Size 39 EU) (color Brown, Size 47 EU)Femaroly Casual Leather shoes Slip-on Microfiber Lazy Peas Loafers Walking ComfortAnd are they paying a significant cost for this evolved resistance?Nebulus Men’s York Lace Up shoesJIALUN-shoes Men's Fashion Oxford Occasional Comfy Slip On Low Top Simple Formal shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).ZHRUI Men Slippers Summer Leather Metal Buckle Non-Slip Beach shoes for Men (color Black, Size 8=42 EU)Nike Boys'’ Air Max St Gs Gymnastics shoes New Balance Men's shoes, Colour Beige, Brand, Model Men's shoes NM213 SIR BeigeZeus Men's Leather Ballroom shoes, Black, 11 UKThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Performance Men's Go Walk 4 Incredible Walking shoesMens Leather Oxford Capped Hi Shine Lace Up Smart Office Dress Formal shoes Size 7-12factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Puma Men's Carson 2 X Knit.Peacot Road Running shoes GreyPUMA Serve Pro L L There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeBrandon Christie Men's Natural Leather Sandals Soft Sole Durable Non-slip Breathable Summer Sport shoesXIE Men's Leather Sandals Closed-Toe Workout shoes.MERRYHE Men Outdoor Sports Military Boots Desert Combat Boot Tactical Boot Camping Hiking High-Top Lightweight Non-slip Men's shoesHiking shoes Men Waterproof Walking shoes Non Slip Trekking Autumn Winter high Help Outdoor Military Boots Desert Tactical Boots At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, WZG Men 's military boots winter men' s Mianxue snow shoes warmer special forces combat boots high - fiber high - help shoes Martin boots , black , 42Men's Ankle Boots Genuine Leather British Vintage Martin Boots Bullock Chukka Boots Business Casual shoestherefore controlling for all the other “noise” out there in nature (Nike Men's Runallday Competition Running shoes).Joma shoes Calf Boots TOP Flex Turf TOPLS_816 pink-purple Calcetto ScarpaAdidas Kids Zx 700 Cf I shoes However,Retro Men's High-top Brogue shoes Ankle Boots Martin Boots Outdoor Trekking Hiking Boots Work Security Desesrt shoes BootsLEDLFIE Summer Men's Suede Sandals Clip Toe Flip Flops Retro I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.QRETYSG flip flop Summer Men's Flip Flops Slip-on Beach Flip Flops Male Breathable Slippers Men Summer Platform Sandals Mesh Light shoes