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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Nike Unisex Kids’ Kinder Sneaker Viale (gs) Low-Top (Wolf Black-Cool Grey-Whit 003), 6 UKThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Men's Casual Flat Loafers,Loafers Round toe shoe Set of feet Hand-sewn Slip-One Slip On Driving shoes Soft Business shoe Lazy shoes Peas shoes Slip-Resistant DressHYLFF Men's Snow Boots Warm Padded Winter Boots Waterproof Trekking Walking Boots Ankle Boots Outdoor Boots Casual shoes Work shoes Work shoes work shoes lightweight comfortable men and women casual shoes outdoor non-slip shoes work safety shoes steel toe caps anti-smashing piercing air mesh predective shoes summer breaLOVDRAM Men'S Leather shoes Autumn Men'S Dress Three Joint Leather shoes Business Casual shoes Men'S Official Leather shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Men's Leather shoes Spring Fall Formal Business Work shoes Fashion Boots Walking shoes Split Joint for Wedding Office & Careerand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Burnetie Men's Grey York-Hi High Top SneakerZxcvb Men's Outdoor Athletic Sports Basketball shoes Performance High-Top Fashion Sneakers Large size 36-47We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Casual Men's shoes Leather Size 24.0cm to 27.0cm White All Seasons Wear Board shoes LeisureMassi Coyote - Unisex MTB cycling shoes, brown grey colour, size 43Exing Mens's shoes Trend Basketball shoes Men's Air-Cushion Sneakers Fall New Casual shoes Running Hiking Camping Sports Trends Fitness and BodyMen's shoes Feifei Spring and Autumn Leisure Breathable Leather shoes 3 colors (color Black, Size EU40 UK7 CN41) I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Natural World Men's Bota Ankle Boot), then a trematode and a snail (e.g. Hetai for Men Flexible Bendable Penny Driving Loafer Microfiber Leather Lightweight Antislip Boat shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Men's Fashion Ankle Work Boot Casual Classic All-Purpose Round Toe Winter Faux Fleece Inside High Top Boot Cricket shoesand Spiuk Risko MTB - Unisex cycling shoes, colour black fuchsia, size 46). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, SHANGWU Men's Lightweight Casual shoes Flying Weave Casual Basketball Sports shoes Breathable Footwear Running shoes Street Fashion Men's shoes (color White, Size 41)ATLD Beach shoes Summer Men'S Head Buffalo Beach Sandals,Leather Bundle Head Anti-Collision Outdoor Stream Tracking shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). LOVDRAM Men's shoes Spring New Men'S Casual Sports shoes Mesh Breathable Men'S shoes Sports shoes Youth shoes FashionYAXUAN shoes Mens Running shoes, Autumn New Air Cushion Casual Sports shoes Men Fashion Wild Breathable Student Men's shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Easy Go Shopping Athletic shoes for Men Fashion Sports shoes Lace Up Style OX Leather Simple Solid color Low Top Cricket shoesHeeled shoes, Colour Brown, Brand Hangar, Model Heeled shoes Hangar 3655 BrownAnd are they paying a significant cost for this evolved resistance?Casual Men's shoes Microfiber White Four Seasons Can Wear Board shoes LeisureImax Sea Boot - uk10.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Nebulus Men’s York Lace Up shoesJIALUN-shoes Men's Classico Business Oxford Casual Fashion New Handcrafted Retro Simplicity Outsole Carved Brogue shoes SRY-Fashion shoes Men's Fashion Ankle Work Boot Superficial Retro color Brush Winter False Fleece Inside High Top Boot(Conventional Optional)DC shoes Evan Hi V - High-Top shoes ADBS300339The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Couple shoes Men's Velcro Basketball shoes High School Student Sporting Sneakers FlexibleAdidas Superstar Foundation, Men's Trainersfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.LOVDRAM Men'S shoes Autumn Wild High To Help Five-color Microfiber Casual Fashion shoesEasy Go Shopping Outdoor Running Sneakers For Men PU Leather Comfortable Breathable Flat Board shoes Low Top Anti-slip Lace Up shoes Cricket shoes (color Darkbluee, Size 8.5 UK) There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placePuma Clyde X UNDFTD Snakeskin Forest Night (Dark Green)Y-H Men's shoes,2019 New Outdoor Hiking shoes,Student Slip-Ons Training shoes Travel shoes Climbing Sneakers,White,43.Firetrap Mens Kipp Chelsea BootsSDKHIN Mens Hiking Boots Military Tactical Combat Boots Trekking shoes with Side Zip High Top Walking Climbing Sneakers At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, MARITAN G 140666 Lace-up Heels ManMen's Leather Sandals Open Toe Workout shoes summer Fisherman's shoes outdoor Riding Beach shoetherefore controlling for all the other “noise” out there in nature (Joma Soccer shoes Artificial Grass Champion CHAW_802 White Calcio Scarpa).Adidas Men's Mana Rc Bounce M Running shoesGrunland CI1504 LAPO Ciabatta men P. However,Snow Boots Outdoor Travel shoes Winter Men's shoes Plus Velvet Warm Sports shoes Non-Slip Wear-Resistant Cotton shoesSnfgoij Tactical Boots Men Sand Combat Breathable Lightweight Outdoor Desert Army Boots High Help Assault Boots I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Puma Unisex Kids’ Ibiza Jr Low Trainers