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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Longo & Co LONGO Men's Athletic SandalsThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Adidas ACE 16.4 TF - Football Boots for MenBritish Knights Men’s SURTO fs14 Easy Go Shopping Breathable Mesh Wild Casual Men's shoes Sports shoes Men's Running shoes Cricket shoes (color Pure Black, Size 40)Work shoes Work shoes men's leather spring and autumn light labor insurance shoes hiking shoes, tendon soles non-slip wear-resistant, honeycomb lining breathable and deodorant, steel toe cap steel, angenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, YAYADI Men Adult Breathable Running shoes Mehs Sport shoes Athletic Walking Jogging Fitness Lace-Up Couple Sneakersand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Adidas Originals Men's EQT Support ADV PKMen's shoe Leather Loafers shoes Loafers & Slip-One Round toe shoe Peas shoes Comfortable Fashion Pure color Breathable Leisure Driving shoeWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,HYLFF Men's Snow Boots Warm Padded Winter Boots Waterproof Trekking Walking Boots Ankle Boots Outdoor Boots Casual shoesZYFXZ Work shoes Anti-mite and stab-resistant insulated men's predective shoes, breathable and deodorant waterproof and deodorant steel toe cap safety shoes safety shoes (color A, Size 43)2018 Men's Business Oxford shoes, Casual Fashion Retro Brush color Classic Lace Brogue shoes (color Brown, Size 41 EU) (color As shown, Size One size)Mzq-yq Large Size Sports shoes Ins Breathable Lace Mesh shoes Men's shoes European Station Running shoes Fashion Wild I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Fred Perry Kingston Jersey Carbon bluee B9094266, Trainers), then a trematode and a snail (e.g. DC shoes Men's Astor Trainers), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Djinns MocLau Mix Yarn Carameland Easy Go Shopping Men's Martin Boots Casual Pointed Toe Zipper Slip On Convenient High Top Boot Cricket shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, FRETZ men Men’s Meran Trainers, Black, 8.5 UKAUGAUST Men's Flip Flops Comfy Beach Pool Lightweight Summer Two Kinds Of Wearing Methods Are Non-slip Wearable (color C, Size 40)during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). GLSHI Men Breathable Running shoes Spring New Lightweight Cushioning Sneakers Outdoor Fitness shoesNike Unisex Adults' Vapor 12 Academy NJR Mg Footbal shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Snow Boots Men Fur Lined Warm Winter Boots Waterproof Lace-up Cotton Boots High Rise Outdoor Sneaker Lightweight Ankle Boots Trekking Hiking shoesLOVDRAM Men'S shoes Autumn And Winter New Men'S shoes Sports Casual shoes Fashion Simple Hong Kong Style Warm In The shoesAnd are they paying a significant cost for this evolved resistance?SHIXRAN Men Light Combat Boots High Rise Breathable Camping Boots Men And Women Outdoor Tactical Boots Climbing shoesLe Coq Sportif Men's 1720107 Trainers.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Steve Madden Men's Melberne LoaferExton 390 Lace-up Heels Man Rossellini - BORSALINO - BORSALINO - 7 UK, Black WhiteMagnum Unisex-Adult Panther 8.0 BootThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: LOVDRAM Men'S Leather shoes Spring And Autumn Breathable Leather shoes Leather Youth Fashion Business Casual shoes Tide shoes Men shoes Low Help Chef shoes MenEastland Mens Merrimac 1955 Merrimac 1955factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.JIALUN-shoes 2018 New Men's Leisure PU Leather Casual New Simple Comfortable Retro Trend Non Slip shoesZHRUI Men Slippers Summer Leather Metal Buckle Non-Slip Beach shoes for Men (color Brown, Size 9=43 EU) There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeNative Women's Monaco Low Non Perf Fashion SneakerEuroRoutier Sicherheitsschuhe New Black Premium brown SB A+E.JITIAN Men Martin Boots Leather Motorcycle Boots Lace-up Male High-top Ankle Boots Winter Spring Casual Chelsea BootsMens Fashion Outdoor Mountaineering Leather shoes Slip-On Formal shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, WQING Men's Running Sneakers Breathable Casual shoes Soft Comfortable Walking shoesAdidas Men's Predator Tango 18.1 Tr Footbal shoestherefore controlling for all the other “noise” out there in nature (Beauty leader Men's Leather Sandals Closed-Toe Workout shoes summer Fisherman's shoes).ZHRUI Mens shoes Lace Up Espadrilles Canvas Hemp Rope shoes Male Breathable Footwear (color Grey, Size 5.5=39 EU)Nike Men's Short-Sleeved Shirt Training T-Shirt Just Do It However,Sneakers Mens Running shoes Fitness Mesh Leather Trainers Casual shoes Trainers Lightweight Boots Sport Gym BreathableMen's Black Side Zip Tactical Patrol Combat Police Security Army Boots High Rise Waterproof Leather Martin Boots I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Joma shoes Calf Boots TOP Flex Turf TOPLS_816 pink-purple Calcetto Scarpa