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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Moodeng Snow Boots For Men and Women Non-Slip Waterproof Furry Slide-On Cotton shoes OutdoorThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Longo & Co LONGO Men's Fashion SandalsDockers by Gerli Men's 38mn009-702850 Boat shoes YAYADI Men shoes Breathable Mesh Lightweight Men Flats Fashion Casual Men'S shoes Designer Male shoes Jogging Fitness shoes Yoga Riding Travel OutdoorMaxguard Unisex Adults' Wallis W112 Safety Clogsgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Puma Men's Evopower 4 IT Football Bootsand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. LOVDRAM Men'S Leather shoes Autumn Men'S Casual Peas shoes Fashion Breathable Driving Men'S Fashion shoes Low To Help Lazy Leather shoesBurnetie Men's Brown York-Hi High Top SneakerWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,YAYADI Men'S Sport Running shoes Lace-Up Exercise Couple Sneakers Breathable Mesh Letter shoes Sneakers For MenMen's Hiking shoes, Light Walking shoes Low Help Waterproof Breathable Non Slip Leisure for Outdoor Sports Trekking Travelling Climbing,Beige,41GLSHI Men Casual Loafer British Fashion Flat shoes Comfortable Lightweight shoes Slip On Driving shoesSanuk Men's M You Got My Back II Slip-On Sandal I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Men's Formal shoes Cowhide Spring Fall Casual Comfort Oxfords Walking shoes Black Brown White Leather shoes), then a trematode and a snail (e.g. Vans Classic Slip-On (Marvel) Hulk Checkerboard VN0A38F7U44 Mens 3.5, Womens 5), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Nike Men's M Nsw Pk Tribute Trousersand Djinns MocLau Mix Yarn Iron). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Easy Go Shopping Fashion Athletic shoes for Men Lace Up Style OX Leather Simple Solid color Comfortable Foot Feeling Sports shoes Cricket shoes (color Black, Size 6.5 UK)Nike Nightgazer, Men’s Gymnastics Gymnastics shoes, White (White White Gum Light Brown Bl 101), 6 UK (39 EU)during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Easy Go Shopping Driving Loafer for Men Boat Moccasins Slip On Style Cowhide Leather Simple Pure color Low Top(Hollow optional) Cricket shoes (color Black, Size 9.5 UK)WFL Canvas shoes men's all black casual shoes flat low cut shoes wild black shoes work shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Worksite LIGHTWEIGHT SPORTS SAFETY TRAINER-7 SS607SM 7 NEWEverlast MX-301 Sneakers Man Grey Green 41And are they paying a significant cost for this evolved resistance?Men's Fashion Chelsea Boots Casual Classic High Top Hard Style Warm Fleece Inside Ankle Boot(Conventional Optional) Cricket shoesGLSHI Men Breathable Knit Running shoes 2018 Autumn New Cushioning Sneakers Lightweight Fitness shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Grunland LINO CE0329 Head of Removable Plantar Man's SlippersHkm Riding Boots Spain Soft Leather Short Wide, Men, Reitstiefel -Spain-, Softleder, kurz weit Puma Womens Suede Platform Satin Wn's shoes In Black Suede Leather 365828-05Men's Ankle Boots, Winter Style High-top Cotton Warm Lace Patent Leather Brogue shoes (Conventional Optional) (color Black, Size 44 EU) (color Warm Black, Size 38 EU)The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Skechers Marter-Life Changer Mens Casual Smart Leather Lace Up Memory Foam shoesZIXUAP Men's fashion low-top Road Running Sneakers Fashion Sport Air Fitness Workout Gym Jogging Walking shoesfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.GAOLIXIA Men's shoes Faux Leather Sneakers Summer Hollow Breathable Sandals Fashion Casual Sports shoes Black WhiteEasy Go Shopping Driving Loafer For Men Boat Moccasins Slip On OX Leather British Style Metaldecor Cricket shoes (color White, Size 9.5 UK) There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placePuma Unisex Adults' Evotouch 2 Fg Football BootsEasy Go Shopping Outdoor Running Sneakers For Men PU Leather Comfortable Breathable Flat Board shoes Low Top Anti-slip Lace Up shoes Cricket shoes (color Darkbluee, Size 8.5 UK).Tiebao Men Road Bicycle Cycling shoes SPD Breathable Ultralight Self-Locking SneakersMERRYHE Military Boots Tactical Boots Desert Combat Training Boot Men Outdoor Lightweight Shock Absorption High-Top Breathable Sports shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, VANS - Sneakers - Men - Sk8 Hi Van Doren Black Palm Tree Motif for menLH Wear-resistant mountaineering cross-country shoes spring and autumn outdoor sports shoes men's low-top waterproof walking non-slip shoes brown,48therefore controlling for all the other “noise” out there in nature (RENMEN Spring Summer Trend Cool Board shoes Sports Casual Running Mesh Men's shoes 39-43, black white).XIANGBAO-Personality Men's Classico Business Oxford Casual Fashion New Handcrafted Retro Simplicity Outsole Carved Brogue shoesMizuno Men's Wave Lightning Z3 Volleyball shoes However,QFYZYZ Men Sport shoes Lace Up Sneakers Athletic TrainersMen's Ankle Boots High-top shoes Lace-Up Outdoor Trekking Hiking Boots Army Military Combat Boots Work Security Police shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Vans U Authentic, Unisex Adults’ Low-top