The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Kempa Men's's Attack Contender Ebbe & Flut Handball shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Nike Men's 845026-701 Tennis shoesNike Boys' Jr Hypervenom Phelon Ii Tf Football Boots Cofra 22300-000.W47 Size 47 S1 P SRC Crevasse Safety shoes - Grey GreenMens's shoes New Spring Fall Kni Breathable Mesh shoes Casual Sneakers Academy Lace-Up Travel shoes (color A, Size 46)generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, MhC Unisex shoes PU(Polyurethane) LED shoes Spring Fall Comfort Crib shoes Ankle Strap Sneakers Basketball shoes Fitness & Cross Training shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Sandals HAIZHEN, Beach shoes, Outdoor Diving, Non-Slip, Quick-Drying, Drifting shoes for Man WomenMaxguard Unisex Adults' Wallis W112 Safety ClogsWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,FeiNianJSh Men's Matte Genuine Leather shoes Low Top shoes Loafers Lace Up Breathable Lined Oxfords CasualZIXUAP Men's autumn tide shoes fashion casual sports shoes students outdoor comfortable non-slip running shoesAdidas Nitrocharge 1.0 Fg, Men’s Football BootsFuxitoggo Men's Fashion Ankle Boots, Casual Retro Comfortable and Wearable Martin Boots (Warm VELVET Optional) (color Warm Yellow, Size 46 EU) (color As shown, Size One size) I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. ZIXUAP Autumn air cushion shoes men's ultra-light comfortable casual sports shoes men's outdoor trend running shoes), then a trematode and a snail (e.g. Salomon Men's Rx Break Flip Flops, (Bright Union bluee Gecko Green), 10 UK 44 2 3 EU), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, KangaROOS K-Yard 3021 B V, Men’s Low-Top Sneakersand Clarks Men's Warley Cory Flip Flops). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, 2018 Men's Business Oxford shoes, Casual Fashion Retro Brush color Classic Lace Brogue shoes (color Brown, Size 41 EU) (color As shown, Size One size)GLSHI Men High Top Basketball shoes Autumn Lightweight Sneakers Outdoor Running shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). LOVDRAM Men's shoes New Breathable Low To Help Casual shoes Sports Cloth shoes Set Foot Wash Denim Canvas shoes MenAmblers Tavistock Mens Casual Boot Mens BootsLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Worksite BLACK S5 PVC SAFETY RIGGER BOOT - 10 SS630SM 10SIKA Motion sandal whether SRC BlackAnd are they paying a significant cost for this evolved resistance?shoes Men's shoes, 2019 Spring Autumn New Couple Sports shoes Mens Fashion Wild Korean Version Air Cushion Running shoes Men Comfortable Casual shoes outdoor (color Red, Size 39)Stonefly Casual shoes for Men, Colour bluee, Brand, Model Casual shoes for Men Season II bluee.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Casual Men's shoes Leather Size 24.0cm to 27.0cm White All Seasons Wear Board shoes LeisureMen's Running shoes, Couples, Breathable Sports shoes JIALUN-shoes Men's Fashion Ankle Work Boot Superficial Retro color Brush Winter False Fleece Inside High Top Boot(Conventional Optional)FGSJEJ Men's Walking Hiking shoes Outdoor Breathable Lace-up Professional Non-Slip Casual Trail Trekking shoes Sports Sneakers Safety shoes (color BROWN, Size 40)The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Nike Men's's Court Bgoldugh Low Prem Basketball shoesReebok Men's Flexagon Fit Multisport Indoor shoesfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Columbia Peakfreak XCRSN II XCEL Low Outdry Sports shoes Men Grey Walking shoesCALZADOS YOWAS Men's Loafer Flats Black Black 15 UK There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeDude shoes Hey Wally Classic EarthHkm Riding Boots Spain Soft Leather Short Wide, Men, Reitstiefel -Spain-, Softleder, kurz weit.Xxoshoe Men's Lightweight Slip On Mesh Sneakers Outdoor Athletic Running shoes Casual Sport shoesBabolat Propulse Clay M Mens Synthetic Material Trainers Red bluee At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, ZANZARA Miro Casual Lace-up Ankle Fashionable Boots for MenLOVDRAM Boots Men's Martin Boots Men'S Fashion Men'S shoes Wild Men'S Cotton shoes Winter Warmth Thickening Fashion High shoestherefore controlling for all the other “noise” out there in nature (Nike Unisex Adults Capri Si Tennis shoes).RIP CURL Men's MOC shoesKXLDres Mens Martin Boots Winter Warm Motorcycle Boots Antiskid Lace Up Flat Boots shoes Comfy Casual Sneaker Trekking Walking Combat Boots Black Khaki However,XTIANUK Mens Sneakers Outdoor Sports Athletic Competition shoes Breathable Flats Gym Fitness TrainersMens Trail Sandals,Summer,Athletic,Breathable,Offroad, Outdoor Leather Sandals Hiking Breathable Sports Beach shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.RENMEN Spring Summer Trend Cool Board shoes Sports Casual Running Mesh Men's shoes 39-43, black