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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Mens Canvas shoes A Pedal Breathable Men's Casual shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Cincasa Menorca Pedro Mens Slipper Mens Slippers (40 EUR) (Black)STACY ADAMS Mens Julius Bike Toe Oxford shoes Artists Johnny Black Cap Toe Oxfords, Men Black Size (8.5 M) USRohde Men's Augsburg Ankle Strap Sandalsgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Adidas Men's Speed Trainer 4 Baseball shoes, Black Night Metallic Carbon, 11.5 M USand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Cofra 22300-000.W42 Size 42 S1 P SRC Crevasse Safety shoes - Grey GreenSandals Men's Flip Flops Non-Slip Beach SummerWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Adidas Men's Inocken Football Boots 11Questra TRX TF Black red White, Black, 41 1 3 EUAdidas VL Court Footwear Black Leather Mens Trainers Sneaker shoesWork shoes Work shoes men's leather spring and autumn light labor insurance shoes hiking shoes, tendon soles non-slip wear-resistant, honeycomb lining breathable and deodorant, steel toe cap steel, anQRETYSG flip flop Sandals Mens shoes Summer Clogs Mens Beach Sandals Outdoor Men Slippers I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Converse All Star Hi Neon, Unisex Adults’ Lace Up shoes), then a trematode and a snail (e.g. Marc O'Polo Men's Beach Sandal Flip Flops, (Black 990), 8 UK), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Nike Boys' Jr Hypervenom Phelon Ii Tf Football Bootsand QRETYSG flip flop Men's Clogs Summer shoes Men Slippers Breathable Non-slip Male Garden shoes Casual Beach Sandals). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Y-H Men's High-top Basketball shoes PU Mesh Spring Fall Comfortable Sneakers Wearable Jogging Fitness Boots Training shoes Student Running shoes (color C, Size 40)Trussardi Jeans Men’s Running Gymnastics shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). LOVDRAM Boots Men's High Top Sports shoes Autumn And Winter Fashion Breathable Casual shoes Fashion Wild Fashion shoes Men'S shoesQuiksilver Shorebreak, Men's Low-Top TrainersLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? K-Swiss Mens Adcourt CVS-L RED-White Trainers FootwearAdidas Men's Questarstrike Fitness shoesAnd are they paying a significant cost for this evolved resistance?ZIXUAP Men's autumn and winter basketball shoes couple fashion wild trend outdoor casual shoesWeiLuShop Summer leisure flip-flops leather soft non-slip sandals outdoor men's sandals.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).LOVDRAM Men'S shoes Autumn And Winter Water-Proof High-Top Sports shoes Thick-Soled Students Fashion shoes Men'S Cotton shoesAdidas Performance Mens Football Boots Swims Penny Loafer, Men’s LoafersZHANGJIA Summer Sandals Men'S Fashion Personality Casual shoes, Wear Resistant Waterproof Beach shoes, Cool Slippers,38,39915 YellowThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Converse Chuck Taylor All Star - C144830FHimalayan Black Leather Waterproof Boot Metal Free Cap & Midsole - 4111factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.WYX shoes Outdoor Sneakers, Men's Hiking shoes, Mesh Sports shoes，Running Travel shoes,Quick-drying shoes,Lightweight Casual shoes,Spring And Summer Breathable shoes, outdoor (color A, Size 48)ZYFXZ Work shoes Anti-mite and stab-resistant insulated men's predective shoes, breathable and deodorant waterproof and deodorant steel toe cap safety shoes safety shoes (color A, Size 43) There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeFeetmat Men's Trail Running shoes Flyknit Mesh Breathable Sport shoes Sneaker for Summer AutumnLOVDRAM Men'S Leather shoes Winter Men'S Casual shoes Fashion shoes Low To Help Men'S shoes Small shoes Students Wild Lace Single shoes.Men's shoes Feifei Winter Fashion Leisure Non-Slip Sports shoes 3 colors (color Khaki, Size EU43 UK9 CN44)Mens Amblers Steel FS84 Safety Boot At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Men's Leather shoes Ankle Work Boot Casual Outdoor Autumn and Winter Vintage High Top Boot Cricket shoesEasy Go Shopping Breathable Steel Head Labor Insurance shoes Spring Fur Predective shoes Anti-smashing Anti-piercing Safety Work shoes Cricket shoes (color Red, Size 40)therefore controlling for all the other “noise” out there in nature (Nunn Bush Mens TJ Wing Tip Oxford Tj Wing Tip Oxford).New Balance Men's 574v1 Fresh Foam SneakerZHRUI Men Slippers Summer Leather Metal Buckle Non-Slip Beach shoes for Men (color Black, Size 8=42 EU) However,Vans Authentic (j S) -Fall 2017- Tibetan Red true WhiteArmy Military Desert Boots For Men's Lace Ups Combat Boots Breathable Hiking shoes For Male Outdoor Trekking Special Forces Boot I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Adidas Men's Cosmic 2 Fitness shoes, Grey (Carbon Amasho Negbás 000)11 UK, (42 EU)