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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. @Sandals Summer Men'S New Korean VersionThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,INMONARCH Mens golden Wedding shoes Wave Wales MJ0042Summer Men Canvas shoes Board shoes Cloth shoes Breathable Casual shoes Low-Cut shoes Fila Men's Skele-Toes Emergence shoes Black, Black Castlerock, 11KEFAS - Suede Italian shoes, Vibram Sole + EVA, Globelite Pink Laser 41generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Easy B's H809 DB Nelson Slip Onand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Cofra 22300-000.W41 Size 41 S1 P SRC Crevasse Safety shoes - Grey GreenCofra COF906-45 Typhoon Safety Wellingtons, Size 45, bluee Red (Pack of 2)We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Hi-Tec Men's Ox Belmont Mid I Waterproof Hiking shoesWillsego Autumn New Large Size Sports Casual shoes Men's shoes Korean Version Of The Tide Men's shoes Breathable Running shoes (color Brown, Size 39)Men's Sneaker Spring and Summer Breathable Casual shoes White Running shoes LeisureSZF228 2019 Basket Basketball shoes Sneakers For Men Air Basket Male Fitness Breathable shoes(red) I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Joma Tkshow 703 Trainer, Cofashion, DE FYLON, Sierra Ground Men), then a trematode and a snail (e.g. Munich Adults’ 3110901 Fitness shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Adidas Men's Cloudfoam Ilation Basketball shoesand LOTTO shoes men low sneakers S5788 AUTOGRAPH). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Florsheim Mens Jet Penny Jet PennyEasy Go Shopping Men's Ankle Boots Casual High-top Vintage and Carved Brogue Work Boots Cricket shoes (color Black, Size 9.5 UK)during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). GLSHI Men's shoes Summer Hollow-Out Breathable Leather Driving shoes Casual Flat Loafers Lace-up Sandals Formal Business Work Black, Yellow BrownConverse Mens Ct As Ox Shield Trainers in Black White-Lace FasteningLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Gola Men's Harrier Suede TrainersLeather Men's Casual Boots, Winter Non-Slip Hiking Boots, Leather Upper Rubber Sole 39-44And are they paying a significant cost for this evolved resistance?PORTMANN Crew Men's Light Design 2-Eye Boat shoes Oiled Leather MocassinZIXUAP Men's shoes Autumn Fashion Wild Trend Casual Sports shoes Men And Women Harajuku Comfortable Non-slip Wear Running shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Walking Outdoor Sandals Men, Summer Pool shoes Waterproof Leather Beach Sport Sand Slip-Resistant 5-12.5KangaROOS K-Marine, Unisex Adults’ Low-Top LOVDRAM Men's shoes Spring New Men'S Casual Sports shoes Mesh Breathable Men'S shoes Sports shoes Youth shoes FashionQRETYSG flip flop Spring Summer Beach Sandalias shoes Men Sandals for Male Casual New Classic Walking Sandals Green blueeThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Men's Leisure Classic Work Boots Leather Business Casual Breathable shoes Round Toe Lace Up Low Top Cricket shoesPuma BLAZE OF GLORY SOFT Khaki Suede Leather Men Sneakers shoes Trinomicfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.QRETYSG flip flop Garden Clog shoes For Men Quick Drying Summer Beach Slipper Flat Breathable Outdoor Sandals Male Gardening shoeMen Sports shoes,Winter New Lightweight Flying Woven shoes Casual Increase Socks shoes Hi-Top Running shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeZHRUI Mens Loafers Casual Fashion shoes Flats Breathable Slip On Swims Loafers Driving shoes (color Navy, Size 6.5 UK)Jordan Men's's Hydro 7 Fitness shoes.New Balance Men's shoes, Colour Beige, Brand, Model Men's shoes NM213 SIR BeigeLOVDRAM Men'S Leather shoes Single Cotton With The Same Men'S shoes Autumn And Winter Sports shoes Leather Deodorant Men'S Cotton shoes Business shoes Men'S Trend Casual shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Baabuk Gus Filzpantoffel Slippers Light GreyEasy Go Shopping Men's Ankle Boots Soft Pig Skin Leather Fashionable Round Toe Lace Up Anti-Skid Wear-Resistant Leisure Sport shoes Cricket shoestherefore controlling for all the other “noise” out there in nature (Dude shoes Hey Wally Classic Earth).QRETYSG flip flop New Men's Slippers Outdoor Walking Male Flat Sneakers Comfortable Summer Man Fashion Slippers PVCColumbia Men's Fish Flip PFG Fisherman Sandal However,Merrell Men's Tetrex Crest Wrap Sport SandalMens Amblers Brown Crazy Horse Leather Dealer Boots Sizes 6 7 8 9 10 11 12 I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.LOVDRAM Men'S Leather shoes Men'S White shoes shoes Fashion Men'S shoes Casual shoes Leather shoes Sports shoes