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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Hhgold Men's Moccasins shoes, Mens Driving Penny Loafers Lace up Genuine Leather Boot Moccasins Flat Soft Sole (color Black, Size 44 EU) (color Dark brown, Size 45 EU)The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,ASICS Men's Gel-kahana 8 Trail RunnerMen's Summer Flip-Flops Non-Slip Leisure Wading Activities Beach shoes Dickies Welton Non Safety Work BootNAMENLOS Men's Football Boots High Top Training Ankle Sole Outdoor Cleats Football shoes Spike High Ankle Men Crampon Training Bootsgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Hetai Men's Leisure Loafers Round Oxfords Toe Casual Flat Penny shoes Soft Leather Upper Slip On Walking Driving shoes Lightweightand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. TYX-SS Summer Breathable Flying Woven Men'S shoes Sports Casual shoes Men'S Single shoes Fashion Tide shoesSneakers Boy’s Basketball shoes High-Top Outdoor Trainers Non-Slip Boots for Unisex KidsWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,YIXINY 17133 Spring And Autumn Black Breathable Lightweight Outdoor Casual Running shoes Men's shoes (Size EU39 UK6 CN39)GAOLIXIA Men's Leather Bean shoes Spring Business Casual shoes British Driving shoes Lazy shoes Outdoor Walking shoes Black bluee BrownMens Leather shoes Black Mission shoes Composite Midsole Knights shoesZLLNSPX Mens Leather shoes Business shoes Dress shoes British Style Pointed Wedding shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. XUE Men's shoes Knit Spring Summer,Casual Athletic shoes,Breathable Running shoes,Lightweight Walking shoes, Light Soles Low-Top Sneakers,Comfort (color C, Size 43)), then a trematode and a snail (e.g. Flair Classic SS Men’s Sport shoes Trainers Running Outdoor Indoor Fitness), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, PUMA Men's Invicto SALA Soccer shoesand Hush Puppies Men's Evan Maddow Oxford). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Autumn And Winter Men's shoes England Wild Leather Casual Men's shoes Fashion Peas shoesWENJHEN Men Business Leather shoes Alligator Thin shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). INMONARCH Mens Beige Brocade Awesome shoes MJ0078Converse Fastbreak Mens Utility Green Mid TrainersLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Hush Puppies Boston Felt GreyPSH 70012491_500 Light Zm 327 S2 Hi Esd Src Safety shoesAnd are they paying a significant cost for this evolved resistance?Unisex Breathable mesh Cloth Hiking shoes Spring Summer Lightweight and Non-Slip Outdoor Sneakers Fashion Trainers for Trekking Camping Climbing and Running (color Light bluee, Size 8 UK)Soldini 20124 2 V06 Sneakers Man.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).QIDI Martin Boots Men Autumn Wild Keep Warm Thicken Booties (color Brown 1, Size US8.5 EU39 UK6.5)Zxcvb Men's Korean Style High Top Platform Fashion Sneaker Sports Casual shoes FeiNianJSh Men's Matte Genuine Leather shoes Low Top Business shoes Hollow Carving Lace Up Breathable Lined OxfordsGLSHI Men Breathable Basketball shoes 2017 Autumn New Shock Fashion Youth Outdoor Sports shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: ZHRUI Mens Loafers Casual Fashion shoes Flats Breathable Slip On Swims Loafers Driving shoes (color Navy, Size 6.5 UK)Men's Chelsea Boots are Casual Comfortable and Simple Winter Fleece Inside Anklfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Men's Version of Casual Slippers Beach shoes Leather Summer Outdoor Anti-Skid SandalsY-H Men's shoes, Spring Fall Mesh Elastic Socks shoes, Student Slip-Ons Comfort Sneakers Running shoes Travel shoes (color Green, Size 41) There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeLOVDRAM Boots Men's New Winter Men'S shoes Fashion Men'S Casual shoes Personality Wild Student shoesZJ Men's shoes Loafers &Amp; Slip-Ons, Comfortable Driving shoes Platform shoes Hair Stylist Nightclub, Personality For Wedding Party &Amp; Evening Night Club Stage.European And American Style Casual Socks shoes Men's Low To Help Sports Single shoes Fly Woven Breathable Men's shoes,Yellow,42UkPuma Evopower 1.2 Mixed Sg, Men’s Football Training At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Mil-tec German Paratrooper Black Leather BootsPortwest Steelite Arx Steel Toecap Safety Trainer - Black or Whitetherefore controlling for all the other “noise” out there in nature (Munich Unisex Adults' Mundial U Fitness shoes).Cofra 63620-000.W45 Size 45 S3 SRC Cefalu Safety shoes - BlackAcorn Mens Moc Spa Thong Slipper However,XUE Men's shoes Leather Spring Summer Fall Comfort Loafers & Slip-ONS Walking shoes Casual Office & Career Light Brown, Dark BrownAdidas Men's Prophere Gymnastics shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Reef Men's Voyage Low-Top Sneakers